Natural Product Research · 2017 · 41 citations · 8 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial ResistanceInfection PreventionMedical MicrobiologyAntimicrobial TherapyBacterial BiofilmsBiofilm FormationBiofilm Formation In InfectionBiofilm-associated ResistanceMicrobial BiofilmsBacterial Biofilm ControlBiofilm InhibitionBiofilm InhibitorsBiofilm-associated InfectionsBiofilm-disrupting AgentsChemical Inhibition Of BiofilmsMetabolic Activity ReductionMethicillin-resistant Staphylococcus Aureus Treatment
The aim of this study was to evaluate the ability of 0.1% thyme oil (TO), trans-cinnamaldehyde (TC), ferulic acid (FA), p-coumaric acid (p-CA), caffeic acid (CA), lavender essential oil (LO), geranium essential oil (GO) and tee tree oil (TTO) to control biofilms formed by methicillin-resistant Staphylococcus aureus (MRSA) strains. Depending on the strains, TO reduced 59.7-85% of biofilm mass, while TC 52.9-82.4% after 48 h of treatment. Reduction of metabolic activity of biofilms in ranges 79.3-86% and 85.9-88.7% was observed after 48 h of TC and TO of treatment, respectively. In the case of some strains, reduction of biofilm mass in the presence of FA, CA, GO, LO and TTO was not observed. This study showed that TO and TC might have therapeutic potential as an inhibitory agents for use in MRSA biofilm-related infections.
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