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Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB

DOIFull Paper Access

70

Citations

27

References

2017

Year

Siyong Gao, Guangsen Zheng, Lin Wang, Yujie Liang, Sien Zhang, Xiaomei Lao, Kan Li, Guiqing Liao
PLoS ONE

Abstract

Our study found that zoledronate was able to suppress preosteoclasts releasing PDGF-BB, resulting in suppression of angiogenesis and osteogenesis. Our study may partly contributed to the mechanism of BRONJ.

References

YearCitations

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