Journal of Microbiology and Biotechnology · 2017 · 14 citations · 0 references
Life SciencesBiotechnologyMicrobiologyBioprocess EngineeringFermentation EngineeringMicrobial MetabolismAntibiotic ProductionBacterial CultivationBioprocess ControlBioprocess OptimizationMicrobial GrowthMicrobial Metabolite ProductionCulture Condition OptimizationCulture Media OptimizationEnzyme Production OptimizationFermentation Media OptimizationFermentation OptimizationFermentation Process OptimizationMedia Optimization
/l·h. The highest herbicidin A concentration of 956.6 mg/l was obtained at 500 rpm, and coincided with the highest relative abundance of hyphae of 100-200 μm length and the highest OUR during cultivation. Based on a constant impeller tip speed, which affects hyphal morphology, herbicidin A production was successfully scaled up from a 5-L jar to a 500-L pilot vessel.