Concepedia

Publication | Open Access

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

DOIFull Paper Access

836

Citations

32

References

2017

Year

Frederick E. Dewey, Viktoria Gusarova, Richard L. Dunbar, Colm O’Dushlaine, Claudia Schurmann, Omri Gottesman, Shane McCarthy, Cristopher V. Van Hout, Shannon Bruse, Hayes M. Dansky,
New England Journal of Medicine

Abstract

Genetic and therapeutic antagonism of ANGPTL3 in humans and of Angptl3 in mice was associated with decreased levels of all three major lipid fractions and decreased odds of atherosclerotic cardiovascular disease. (Funded by Regeneron Pharmaceuticals and others; ClinicalTrials.gov number, NCT01749878 .).

References

YearCitations

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