Effects of genetic variants in UGT1A1, SLCO1B3, ABCB1, ABCC2, ABCG2, ORM1 on PK/PD of telmisartan in Chinese patients with mild to moderate essential hypertension - Concepedia

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Effects of genetic variants in UGT1A1, SLCO1B3, ABCB1, ABCC2, ABCG2, ORM1 on PK/PD of telmisartan in Chinese patients with mild to moderate essential hypertension

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References

2017

Year

Qi Pei, Yang Liu, Hongyi Tan, Shikun Liu, Yang Liu, Lu Huang, Ronghui Li, Qian Wan, Jie Huang, Chengxian Guo,

International Journal of Clinical Pharmacology and Therapeutics

Abstract

Variation of UGT1A1 (rs4124874) affects PK of telmisartan in Chinese patients, highlighting the value of genetic testing in precision medicine as the telmisartan dose could be adjusted based on UGT1A1 genetic variations. .