Phylogenic analysis and forensic genetic characterization of Chinese Uyghur group via autosomal multi STR markers

Abstract

// Xiaoye Jin 1, 2, 3, * , Yuanyuan Wei 1, 2 , Jiangang Chen 4 , Tingting Kong 1, 2 , Yuling Mu 1, 2, 3 , Yuxin Guo 1, 2, 3 , Qian Dong 1, 2, 3 , Tong Xie 5 , Haotian Meng 1, 2 , Meng Zhang 6 , Jianfei Li 7 , Xiaopeng Li 8 and Bofeng Zhu 1, 2, 5, * 1 Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, PR China 2 Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, PR China 3 College of Medicine and Forensics, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, PR China 4 Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi, 830011, Xinjiang, PR China 5 Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, PR China 6 Department of Orthopaedics, Ankang City Central Hospital, Ankang, 725000, Shaanxi, PR China 7 Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, PR China 8 Department of Ultrasound, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, PR China * These authors contributed equally to this work Correspondence to: Xiaopeng Li, email: lixpxjtu@163.com Keywords: short tandem repeats (STRs), inter-population differentiation, Uyghur ethnic group, phylogenic analysis, PCA Received: March 28, 2017      Accepted: May 06, 2017      Published: May 18, 2017 ABSTRACT We investigated the allelic frequencies and forensic descriptive parameters of 23 autosomal short tandem repeat loci in a randomly selected sample of 1218 unrelated healthy Uyghur individuals residing in the Xinjiang Uyghur Autonomous Region, northwest China. A total of 281 alleles at these loci were identified and their corresponding allelic frequencies ranged from 0.0004 to 0.5390. The combined match probability and combined probability of exclusion of all loci were 5.192 × 10 –29 and 0.9999999996594, respectively. The results of population genetic study manifested that Uyghur had close relationships with those contiguous populations, such as Xibe and Hui groups. In a word, these autosomal short tandem repeat loci were highly informative in Uyghur group and the multiplex PCR system could be used as a valuable tool for forensic caseworks and population genetic analysis.