Preparation of 212 Pb-labeled monoclonal antibody using a novel 224 Ra-based generator solution

Abstract

The current work demonstrates a novel method of producing ²¹²Pb-based radioimmunoconjugates from a ²²⁴Ra-solution, which may be simpler and less time-consuming for the end user compared with the method established for use in clinical trials of ²¹²Pb-TCMC-trastuzumab.