Antimicrobial Agents and Chemotherapy · 2017 · 15 citations · 24 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial ResistanceMedical MicrobiologyMicrobial GeneticsAntibacterial ResistanceAntibiotic ResistanceAntibiotic Resistance GeneticsAntibiotic Resistance MechanismsAntimicrobial Resistance GenomicsResistance GenesAntibiotic Resistance ProfilingBase SubstitutionsCampylobacter ResistanceDrug Resistance Pattern AnalysisFluoroquinolone AntibioticsFluoroquinolone Resistance MechanismsSubstitutions
ABSTRACT Sequence analysis of 79 ciprofloxacin-resistant Campylobacter jejuni isolates collected in China showed resistance-related sequence variations in gyrA and CmeR-Box. All the isolates contain an identical Thr-86-Ile substitution in GyrA. Several novel CmeR-Box variations, including point substitutions, deletion, and insertion, were identified. The point insertion or deletion led to dramatically reduced binding of CmeR to the cmeABC promoter, which significantly increases the expression of cmeABC and contributes to the high fluoroquinolone resistance.
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