Concepedia

Synthesis and biological evaluation of novel technetium-99m-labeled phenylquinoxaline derivatives as single photon emission computed tomography imaging probes targeting β-amyloid plaques in Alzheimer's disease

Shimpei Iikuni, Masahiro Ono, Keiichi Tanimura, Hiroyuki Watanabe, Masashi Yoshimura, Hideo Saji

RSC Advances · 2017 · 11 citations · 33 references

DOIFull text

Open access

Concepts

Abstract

The development of an imaging probe targeting β-amyloid (Aβ) plaques in Alzheimer's disease labeled with technetium-99m, the most commonly used radioisotope for clinical diagnoses, has been strongly anticipated.

References

33

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

William E. Klunk, Henry Engler, Agneta Nordberg et al. · Annals of Neurology · 2004 · 4.5K citations

, , +15

Synthesis and Evaluation of <sup>11</sup>C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents

Chester A. Mathis, Yanming Wang, Daniel P. Holt et al. · Journal of Medicinal Chemistry · 2003 · 983 citations · Full text

, , +8

In Vivo Imaging of Amyloid Deposition in Alzheimer Disease Using the Radioligand <sup>18</sup>F-AV-45 (Flobetapir F 18)

Dean F. Wong, Paul B. Rosenberg, Yun Zhou et al. · Journal of Nuclear Medicine · 2010 · 677 citations · Full text

, , +14

Phase 1 Study of the Pittsburgh Compound B Derivative <sup>18</sup>F-Flutemetamol in Healthy Volunteers and Patients with Probable Alzheimer Disease

Natalie Nelissen, Koen Van Laere, Lennart Thurfjell et al. · Journal of Nuclear Medicine · 2009 · 339 citations · Full text

, , +17