Concepedia

Cytokines and Chemokines Involved in Acute Retinal Necrosis

L. de Visser, Joke H. de Boer, G T Rijkers, Karin Wiertz, Henk‐Jan van den Ham, Rob J. de Boer, Anton M. van Loon, Aniki Rothová, D. F. de Groot-Mijnes

Investigative Ophthalmology & Visual Science · 2017 · 41 citations · 39 references

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Abstract

The pathogenesis of ARN is characterized by the presence of predominantly proinflammatory cytokines and chemokines with high expression levels as compared to other infectious causes of uveitis. There are no indications for an obvious Th-1 or Th-17 pathway. The combined data suggest that immune mediator expression is related to severity of disease, which is more fulminant in ARN, rather than to a specific uveitis entity.

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