Anti-Apolipoprotein A-1 IgG Predict All-Cause Mortality and Are Associated with Fc Receptor-Like 3 Polymorphisms

Abstract

Anti-apoA-1 IgG levels (a) independently predict all-cause mortality in the general population and (b) are linked to <i>FCRL3</i>, a susceptibility gene for numerous autoimmune diseases. Our findings indicate that preclinical autoimmunity to anti-apoA-1 IgG may represent a novel mortality risk factor.