Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

Abstract

The Trypanosoma species used in this study included a clinically relevant human CSF isolate and bloodstream form (BSF) from a patient with sleeping sickness. A cloned derivative from this parasite termed "IL1852" was originally identified as a T.b. gambiense and was denoted accordingly in the manuscript.