Neurochemical effects of the R form of α-lipoic acid and its neuroprotective mechanism in cellular models of Parkinson’s disease

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

J. William Langston, Philip L. Ballard, James W. Tetrud et al. · Science · 1983 · 4.9K citations

Life Sciences, Neuroscience, Pharmacology +14

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark et al. · Journal of Biological Chemistry · 2007 · 4.5K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler, Kira M. Holmström, Diana Skujat et al. · Nature Cell Biology · 2010 · 2.8K citations

Life Sciences, Cell Biology, Molecular Genetics +12

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

Joo‐Ho Shin, Han Seok Ko, Ho Chul Kang et al. · Cell · 2011 · 943 citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

Jung H. Suh, Swapna V. Shenvi, Brian Dixon et al. · Proceedings of the National Academy of Sciences · 2004 · 770 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17