Angiogenic Mechanisms of Human CD34 ⁺ Stem Cell Exosomes in the Repair of Ischemic Hindlimb

Abstract

Collectively, our results have demonstrated a novel mechanism by which cell-free CD34Exo mediates ischemic tissue repair via beneficial angiogenesis. Exosome-shuttled proangiogenic miRNAs may signify amplification of stem cell function and may explain the angiogenic and therapeutic benefits associated with CD34⁺ stem cell therapy.