Concepedia

Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis

Catherine Y. Cheng, Nuria Martinez Gutierrez, Mardiana Marzuki, Taylor W. Foreman, Bhairav Paleja, Bernett Lee, Akhila Balachander, Jinmiao Chen, Liana Tsenova, Natalia Kurepina,

Science Immunology · 2017 · 132 citations · 37 references

DOIFull text

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Concepts

Abstract

infection. Collectively, these results provide a link between SIRT1 activation and TB pathogenesis and indicate a potential of SIRT1 activators in designing an effective and clinically relevant host-directed therapies for TB.

References

37

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