Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue

Deanna L. Plubell, Phillip A. Wilmarth, Yuqi Zhao, Alexandra M Fenton, Jessica Minnier, Ashok P. Reddy, John Klimek, Xia Yang, Larry L. David, Nathalie Pamir

Molecular & Cellular Proteomics · 2017 · 391 citations · 64 references

DOIFull text

Open access

Concepts

Abstract

YAP1, HIP1, NDRG1, PRKCD, MUL1) pathways. Using our adipose tissue tailored approach we have identified both age-related and high fat diet specific proteomic signatures highlighting a pronounced involvement of arginine metabolism in response to advancing age, and branched chain amino acid metabolism in early response to high fat feeding. Data are available via ProteomeXchange with identifier PXD005953.

References

64