Concepedia

Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice

Anthony J. Roecker, Melissa S. Egbertson, Kristen L. Jones, Robert Gomez, Richard L. Kraus, Yuxing Li, Amy Jo Koser, Mark O. Urban, Rebecca M. Klein, Michelle K. Clements,

Bioorganic & Medicinal Chemistry Letters · 2017 · 45 citations · 25 references

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25

The Economic Costs of Pain in the United States

Darrell J. Gaskin, Patrick Richard · Journal of Pain · 2012 · 2.4K citations

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An SCN9A channelopathy causes congenital inability to experience pain

James J. Cox, Frank Reimann, Adeline K. Nicholas et al. · Nature · 2006 · 1.6K citations · Full text

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Mutations in <i>SCN9A</i>, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

Ying Yang · Journal of Medical Genetics · 2004 · 795 citations · Full text

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Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

Sulayman D. Dib‐Hajj, Anthony M. Rush, T.R. Cummins et al. · Brain · 2005 · 484 citations · Full text

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Postoperative Opioid-induced Respiratory Depression

Lorri A. Lee, Robert A. Caplan, Linda S. Stephens et al. · Anesthesiology · 2015 · 453 citations · Full text

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