Concepedia

Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen

Daniel S. Palacios, Erik L. Meredith, Toshio Kawanami, Christopher M. Adams, Xin Chen, Véronique Darsigny, Erin Geno, Mark Palermo, Daniel Baird, Geoffrey M. Boynton,

Bioorganic & Medicinal Chemistry Letters · 2017 · 17 citations · 15 references

DOI

Concepts

References

15

The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

Javier R. Revollo, Andrew A. Grimm, Shin‐ichiro Imai · Journal of Biological Chemistry · 2004 · 993 citations · Full text

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FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.

Max Hasmann, Isabel Schemainda · PubMed · 2003 · 635 citations

, , +17

Intramolecular Hydrogen Bonding in Medicinal Chemistry

Bernd Kuhn, Peter J. Mohr, Martin Ståhl · Journal of Medicinal Chemistry · 2010 · 568 citations

, , +15

Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents

Javed Khan, Xiao Tao, Liang Tong · Nature Structural & Molecular Biology · 2006 · 260 citations

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NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

B Wang, Md Kamrul Hasan, E. Alvarado et al. · Oncogene · 2010 · 248 citations

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