Concepedia

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

Alyssa Carey, David K. Edwards, Christopher A. Eide, Laura F. Newell, Elie Traer, Bruno C. Medeiros, Daniel A. Pollyea, Michael W. Deininger, Robert H. Collins, Jeffrey Tyner,

Cell Reports · 2017 · 270 citations · 38 references

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Abstract

cells from IL-1-mediated growth suppression. These results highlight the importance of ex vivo functional screening to identify common and actionable extrinsic pathways in genetically heterogeneous malignancies and provide impetus for clinical development of IL-1/IL1R1/p38MAPK pathway-targeted therapies in AML.

References

38

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

New England Journal of Medicine · 2013 · 5.2K citations · Full text

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IL-1 is required for tumor invasiveness and angiogenesis

Elena Voronov, Dror S. Shouval, Yakov Krelin et al. · Proceedings of the National Academy of Sciences · 2003 · 1K citations · Full text

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

Fumihiko Ishikawa, Shuro Yoshida, Yoriko Saito et al. · Nature Biotechnology · 2007 · 975 citations

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Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Eric M. Pietras, Cristina Mirantes-Barbeito, Sarah Fong et al. · Nature Cell Biology · 2016 · 705 citations

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Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

DN Haylock, LB To, TL Dowse et al. · Blood · 1992 · 352 citations · Full text

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