Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

Abstract

A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and fully characterized. Most of the compounds displayed antiparasitic activity against <i>Trypanosoma cruzi</i> and <i>Leishmania donovani</i>. The most active compounds were assayed as potential <i>Tc</i>CYP51 inhibitors.