Concepedia

Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation

Lixia Yu, Wei‐Guang Wang, Wei Pang, Zhong-hai Xiao, Yugang Jiang, Yan Hong

Journal of Alzheimer s Disease · 2017 · 73 citations · 27 references

DOI

Abstract

Our findings indicated that the combination of lycopene and vitamin E antioxidants acted in a synergistic fashion to bring significant effects against oxidative stress in tauopathies.

References

27

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

Mubeen A. Ansari, Stephen W. Scheff · Journal of Neuropathology & Experimental Neurology · 2010 · 585 citations · Full text

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Evidence of increased oxidative damage in subjects with mild cognitive impairment

Jeffrey N. Keller, Frederick A. Schmitt, Stephen W. Scheff et al. · Neurology · 2005 · 537 citations

Tau Filament Formation in Transgenic Mice Expressing P301L Tau

Jürgen Götz, Feng Chen, Robi Barmettler et al. · Journal of Biological Chemistry · 2001 · 512 citations · Full text

Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease

Manuela Pădurariu, Alin Ciobîcă, Lucian Hriţcu et al. · Neuroscience Letters · 2009 · 374 citations

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