Comprehensive Analysis of Constraint on the Spatial Distribution of Missense Variants in Human Protein Structures

The Protein Data Bank

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Life Sciences, Biochemistry, Bioinformatics +10

A general method applicable to the search for similarities in the amino acid sequence of two proteins

Saul B. Needleman, Christian D. Wunsch · Journal of Molecular Biology · 1970 · 11.5K citations

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Analysis of protein-coding genetic variation in 60,706 humans

Monkol Lek, Konrad J. Karczewski, Eric Vallabh Minikel et al. · Nature · 2016 · 10.3K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Statistical significance for genomewide studies

John D. Storey, Robert Tibshirani · Proceedings of the National Academy of Sciences · 2003 · 10.1K citations · Full text

Life Sciences, Biostatistics, Genetics +13

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shikshya Shrestha, Steven M. Offer · Medical Epigenetics · 2016 · 9K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17