Concepedia

Identification and characterization of monoclonal antibody fragments cleaved at the complementarity determining region using orthogonal analytical methods

Wenhua Li, Bin Yang, Dongmei Zhou, Jun Xu, Wenjia Li, Wen-Chen Suen

Journal of Chromatography B · 2017 · 33 citations · 24 references

DOI

Concepts

References

24

Non-enzymatic hinge region fragmentation of antibodies in solution

Armando J. Cordoba, Bao-Jen Shyong, Deirdre Breen et al. · Journal of Chromatography B · 2005 · 186 citations

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β-Elimination and Peptide Bond Hydrolysis:  Two Distinct Mechanisms of Human IgG1 Hinge Fragmentation upon Storage

Steven L. Cohen, Colleen Price, Josef Vlasak · Journal of the American Chemical Society · 2007 · 150 citations

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Developments and Challenges for mAb-Based Therapeutics

Sumit Goswami, Wei Wang, Tsutomu Arakawa et al. · Antibodies · 2013 · 148 citations · Full text

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Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

Markus Haberger, Anna-Katharina Heidenreich, Oxana Pester et al. · mAbs · 2015 · 139 citations · Full text

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Characterization of the stability of a fully human monoclonal IgG after prolonged incubation at elevated temperature

Hongcheng Liu, Georgeen Gaza‐Bulseco, Joanne Sun · Journal of Chromatography B · 2006 · 122 citations

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