Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Jeff L. Staudinger, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2001 · 1.4K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +13

A T cell-dependent experimental liver injury in mice inducible by concanavalin A.

Gisa Tiegs, Julia Hentschel, Albrecht Wendel · Journal of Clinical Investigation · 1992 · 1.1K citations · Full text

Veterinary Medicine, Immunology, Pathology +15

Chemokine involvement in hepatic ischemia/reperfusion injury in mice: Roles for macrophage inflammatory protein-2 and kupffer cells

Alex B. Lentsch, Hiroyuki Yoshidome, William G. Cheadle et al. · Hepatology · 1998 · 335 citations

Veterinary Medicine, Immunology, Pathology +17

Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes

Thomas Langmann, Christoph Moehle, Richard Mauerer et al. · Gastroenterology · 2004 · 334 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +13

Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression

Yatrik M. Shah, Xiaochao Ma, Keiichirou Morimura et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 2006 · 230 citations

Life Sciences, Immunology, Pharmacology +17