Nuclear Receptors CAR and PXR Cross Talk with FOXO1 To Regulate Genes That Encode Drug-Metabolizing and Gluconeogenic Enzymes

Susumu Kodama, Chika Koike, Masahiko Negishi, +1

Molecular and Cellular Biology

Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene

Susumu Kodama, Rick Moore, Yukio Yamamoto, +1

Biochemical Journal

Pregnane X Receptor PXR Activates the GADD45β Gene, Eliciting the p38 MAPK Signal and Cell Migration

Susumu Kodama, Masahiko Negishi

Journal of Biological Chemistry

P38 MapkTumor BiologyTranscriptional RegulationSignaling PathwayCell Regulation +18

Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid

Taiki Abe, Mirei Takahashi, Makoto Kano, +11

Archives of Toxicology

Environmental ChemistryMedicineNuclear Receptor CarChemical PollutantToxicology +3

PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice

Maya Okamura, Ryota Shizu, Taiki Abe, +4

Cells

Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure

Susumu Kodama, Fardin Hosseinpour, Joyce A. Goldstein, +1

Nucleic Acids Research

Epigenetic ChangeGeneticsPxr ActivationCancer BiologyEpigenetics +20

Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice

Ryota Shizu, Satoshi Benoki, Yuki Numakura, +4

PLoS ONE

X ReceptorImmunologyCell ProliferationMolecular PharmacologyHepatotoxicity +15

Leukocyte glutathione peroxidase deficiency in a male patient with chronic granulomatous disease

Ichiro Matsuda, Yogo Oka, Naoyuki Taniguchi, +4

The Journal of Pediatrics

GlomerulonephritisAllergyChronic Granulomatous DiseaseMedicineGranulocyte +6

Role of YAP Activation in Nuclear Receptor CAR-Mediated Proliferation of Mouse Hepatocytes

Taiki Abe, Yuto Amaike, Ryota Shizu, +7

Toxicological Sciences

Transcriptional RegulationSignaling PathwayCell RegulationReceptor Tyrosine KinaseLiver Hypertrophy +14

Nuclear Xenobiotic Receptor Pregnane X Receptor Locks Corepressor Silencing Mediator for Retinoid and Thyroid Hormone Receptors (SMRT) onto the CYP24A1 Promoter to Attenuate Vitamin D3 Activation

Yoshihiro Konno, Susumu Kodama, Rick Moore, +2

Molecular Pharmacology