Phenolic 1,3‐diketones attenuate lipopolysaccharide‐induced inflammatory response by an alternative magnesium‐mediated mechanism

Abstract

These results indicate that phenolic 1,3-diketones, with a structural motif able to coordinate magnesium ions, can modulate LPS-mediated TLR4-MD-2 signalling. Taken together, these studies identify a previously uncharacterized mechanism involving magnesium, underlying the inflammatory responses to LPS.