Concepedia

Clinical application of polymeric micelles for the treatment of cancer

Aida Varela-Moreira, Yang Shi, Marcel H.A.M. Fens, Twan Lammers, Wim E. Hennink, Raymond M. Schiffelers

Materials Chemistry Frontiers · 2017 · 167 citations · 81 references

DOIFull text

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Concepts

Abstract

Recent progress of polymeric micelle formulations currently under clinical evaluation for the treatment of cancer.

References

81

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

Horacio Cabral, Yu Matsumoto, Kazue Mizuno et al. · Nature Nanotechnology · 2011 · 2.4K citations

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Design of Environment‐Sensitive Supramolecular Assemblies for Intracellular Drug Delivery: Polymeric Micelles that are Responsive to Intracellular pH Change

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Acidic extracellular microenvironment and cancer

Shigeyuki Ozawa, Chihiro Miyamoto, Yojiro Maehata et al. · Cancer Cell International · 2013 · 1.3K citations · Full text

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Hypersensitivity reactions from taxol.

R B Weiss, Ross C. Donehower, Peter H. Wiernik et al. · Journal of Clinical Oncology · 1990 · 1.2K citations

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Preparation and Biological Characterization of Polymeric Micelle Drug Carriers with Intracellular pH-Triggered Drug Release Property:  Tumor Permeability, Controlled Subcellular Drug Distribution, and Enhanced in Vivo Antitumor Efficacy

Younsoo Bae, Nobuhiro Nishiyama, Shigeto Fukushima et al. · Bioconjugate Chemistry · 2004 · 732 citations

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