bioRxiv (Cold Spring Harbor Laboratory) · 2017 · 142 citations · 16 references
Life SciencesBiostatisticsGeneticsGenetic EpidemiologyHuman GeneticsStatistical GeneticsGenome-wide Association StudiesGenotype-phenotype Association AnalysisGenotype-phenotype CorrelationMarker-trait AssociationPolygenic TraitsQuantitative Trait Locus MappingGenetic Association Meta-analysisGenetic Risk VariantsHuman TraitsPersonality Polygenic ScoresPolygenic Score ModelingPolygenic Trait AnalysisSingle-nucleotide Polymorphism Association AnalysisSingle-nucleotide Variants
Genome-wide association studies (GWAS) on a wide range of important human traits have identified hundreds of variants in multi-cohort meta-analyses that have highly significant associations (p<5 x10-8) that replicate across studies. However, the identified genetic variants, or single nucleotide
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Cohort Profile: the Health and Retirement Study (HRS)
Amanda Sonnega, Jessica D. Faul, Mary Beth Ofstedal et al. · International Journal of Epidemiology · 2014 · 2.2K citations · Full text
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hana Lango Allen, Karol Estrada, Guillaume Lettre et al. · Nature · 2010 · 2.1K citations · Full text
Power and Predictive Accuracy of Polygenic Risk Scores
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