Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases

Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis

Carmel Toomes, Jacqueline A. James, Andrew J. Wood et al. · Nature Genetics · 1999 · 489 citations · Full text

Periodontal Disease, Genetics, Pathogenesis +7

Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B<i>in vivo</i>

Christine T. N. Pham, Timothy J. Ley · Proceedings of the National Academy of Sciences · 1999 · 392 citations

Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis

April M. Adkison, Sofia Z. Raptis, Diane G. Kelley et al. · Journal of Clinical Investigation · 2002 · 357 citations · Full text

Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis

April M. Adkison, Sofia Z. Raptis, Diane G. Kelley et al. · Journal of Clinical Investigation · 2002 · 341 citations

Immunology, Immune Regulation, Acute Experimental Arthritis +24

Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome

Thomas C. Hart, Patricia Hart, Donald W. Bowden et al. · Journal of Medical Genetics · 1999 · 335 citations · Full text