Concepedia

Publication | Open Access

Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer

DOIFull Paper Access

41

Citations

30

References

2017

Year

Tatsuaki Takeda, Hiromasa Yamamoto, Hirotaka Kanzaki, Ken Suzawa, Takahiro Yoshioka, Shuta Tomida, Xiaojiang Cui, Ramachandran Murali, Kei Namba, Hiroki Sato,
PLoS ONE

Abstract

Yes1 plays an important role in acquired resistance to trastuzumab and lapatinib in HER2-positive breast cancer. Our data suggest that pharmacological inhibition of Yes1 may be an effective strategy to overcome resistance to trastuzumab and lapatinib.

References

YearCitations

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