Studies on Scutellariae Radix

M. Kubo, Yoshiyuki Kimura, Tsutomu Odani, +2

Planta Medica

BiologyActive PrinciplesMedicinal ChemistryBiochemistryActive Ingredient +13

Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in <i>EGFR</i> -Mutant Non–Small Cell Lung Cancer Cells

Kei Namba, Kazuhiko Shien, Yuta Takahashi, +10

Molecular Cancer Research

Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR‐TKIs in non‐small cell lung cancer

Hiroki Sato, Hiromasa Yamamoto, Masakiyo Sakaguchi, +13

Cancer Science

Newly developed anti‐S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis

Rie Kinoshita, Hiroki Sato, Akira Yamauchi, +24

International Journal of Cancer

Antitumor activity of pan‐<scp>HER</scp> inhibitors in <scp>HER</scp>2‐positive gastric cancer

Takahiro Yoshioka, Kazuhiko Shien, Kei Namba, +10

Cancer Science

Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer

Tatsuaki Takeda, Hiromasa Yamamoto, Hirotaka Kanzaki, +17

PLoS ONE

Acquired resistance mechanisms to afatinib in <i><scp>HER</scp>2</i>‐amplified gastric cancer cells

Takahiro Yoshioka, Kazuhiko Shien, Tatsuaki Takeda, +11

Cancer Science

Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway

Tomoaki Ohtsuka, Masakiyo Sakaguchi, Hiromasa Yamamoto, +16

Scientific Reports

Comparative mutational evaluation of multiple lung cancers by multiplex oncogene mutation analysis

Yuta Takahashi, Kazuhiko Shien, Shuta Tomida, +12

Cancer Science

Surgical OncologyGeneticsPathologyOncologyTumor Heterogeneity +16

Elacridar, a third-generation ABCB1 inhibitor, overcomes resistance to docetaxel in non-small cell lung cancer

Haiyang Chen, Kazuhiko Shien, Ken Suzawa, +11

Oncology Letters