Concepedia

Discovery of phenyl acetamides as potent and selective GPR119 agonists

Cheng Zhu, Liping Wang, Yuping Zhu, Zack Zhiqiang Guo, Ping Liu, Zhiyong Hu, Jason W. Szewczyk, Ling Kang, Gary G. Chicchi, Anka G Ehrhardt,

Bioorganic & Medicinal Chemistry Letters · 2017 · 12 citations · 15 references

Open access

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryMolecular PharmacologySynthetic Medicinal ChemistryHit-to-lead OptimizationLigand BindingMolecular DockingNatural Product Drug DiscoveryPotency OptimizationReceptor PharmacologyBioactive Compound LibrariesChemical Synthesis Of AnaloguesMedicinal Chemistry ApplicationsReceptor Binding Optimization

References

15

Evaluation of Various Dissolution Media for Predicting In Vivo Performance of Class I and II Drugs

Eric Galia, Eleftheria Nicolaides, D. Hörter et al. · Pharmaceutical Research · 1998 · 923 citations

Pharmacy, Pharmaceutics, Pharmacology +16

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

Zhi‐Liang Chu, Christopher J. Carroll, Jean Alfonso et al. · Endocrinology · 2008 · 380 citations

Life Sciences, Endocrinology, Physiology +17

A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release

Zhi‐Liang Chu, Robert M. Jones, Hongmei He et al. · Endocrinology · 2007 · 292 citations

Medicine, Endocrinology, Pharmacology +17

Pharmaceutical profiling in drug discovery

Edward H. Kerns · Drug Discovery Today · 2003 · 283 citations

Pharmacy, Pharmacology, Drug Discovery +6

In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective

Valeria Chu, Heidi J. Einolf, Raymond Evers et al. · Drug Metabolism and Disposition · 2009 · 161 citations

Medicine, Pharmacokinetics, Pharmacology +17