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The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

DOIFull Paper Access

282

Citations

43

References

2016

Year

Chunwan Lu, Amy V. Paschall, Huidong Shi, Natasha M. Savage, Jennifer L. Waller, María E. Sabbatini, Nicholas H. Oberlies, Cedric J. Pearce, Kebin Liu
JNCI Journal of the National Cancer Institute

Abstract

The Fas-FasL/CTLs and the MLL1-H3K4me3-PD-L1 axis play contrasting roles in pancreatic cancer immune surveillance and evasion. Targeting the MLL1-H3K4me3 axis is an effective approach to enhance the efficacy of checkpoint immunotherapy against pancreatic cancer.

References

YearCitations

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