Metal–free Decarboxylative Amination: An Alternative Approach Towards Regioselective Synthesis of β‐Carboline <i>N</i>‐fused Imidazoles

Abstract

Abstract Due to significant activity profile and natural abundance of β‐carboline containing alkaloids, β‐carboline N ‐fused imidazole derivatives were designed and iodine assisted efficient approach was formulated for the regioselective synthesis of designed prototypes via decarboxylative amination of natural α‐amino acids with 1‐formyl pyrido[3,4‐ b ]indoles. Additionally, oxidative amination with benzyl amines was also investigated for the synthesis of these β‐carboline D‐ring containing frameworks. magnified image