Cu(NO ₃ ) ₂ -catalysed Direct Synthesis of 5-substituted 1 <i>H</i> -tetrazoles from Alcohols or Aldehydes

Abstract

A simple, convenient and practical protocol to synthesise 5-substituted 1 H-tetrazoles from alcohols or aldehydes is reported. Using ammonia and sodium azide as nitrogen sources and Cu(NO 3 ) 2 as catalyst, benzylic alcohols and benzaldehydes were directly converted into 5-substituted 1 H-tetrazoles in a one-pot procedure.