Concepedia

Relationship Between Some Single-nucleotide Polymorphism and Response to Hydroxyurea Therapy in Iranian Patients With β-Thalassemia Intermedia

Mehran Karimi, Tahereh Zarei, Sezaneh Haghpanah, Mohamad Moghadam, Ahmad Ebrahimi, Narges Rezaei, Ghazaleh Heidari, Afsaneh Vazin, Maryam Khavari

Journal of Pediatric Hematology/Oncology · 2017 · 11 citations · 22 references

DOI

Abstract

None of the evaluated SNPs in our study showed significant association with HU response. Further larger studies and evaluation of other genes are suggested.

References

22

Genome-wide association study shows <i>BCL11A</i> associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia

Manuela Uda, Renzo Galanello, Serena Sanna et al. · Proceedings of the National Academy of Sciences · 2008 · 655 citations · Full text

, , +19

Beta-thalassemia

Genetics in Medicine · 2010 · 634 citations · Full text

DNA polymorphisms at the <i>BCL11A</i> , <i>HBS1L-MYB</i> , and β- <i>globin</i> loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

Guillaume Lettre, Vijay G. Sankaran, Marcos Bezerra et al. · Proceedings of the National Academy of Sciences · 2008 · 534 citations · Full text

Hydroxyurea induces fetal hemoglobin by the nitric oxide–dependent activation of soluble guanylyl cyclase

Vladan P. Čokić, Reginald D. Smith, Bojana Beleslin‐Čokić et al. · Journal of Clinical Investigation · 2003 · 312 citations · Full text

Genetic modifiers of beta-thalassemia.

Swee Lay Thein · PubMed · 2005 · 191 citations

, , +13