Asymmetric synthesis of C–F quaternary α-fluoro-β-amino-indolin-2-ones via Mannich addition reactions; facets of reactivity, structural generality and stereochemical outcome

Abstract

An asymmetric detrifluoroacetylative Mannich reaction between <italic>in situ</italic> generated tertiary enolates and sulfinyl-imines has been explored. The reaction provides a new access to α-fluoro-β-amino-indolin-2-ones with tetrasubstituted fluorinated stereogenic center.