Catalytic Enantioselective Fluorination ofβ-Ketoesters

Abstract

Isolated and crystallized [Ti(TADDOLato)] complexes were used as catalysts for the first catalytic enantioselective (up to 90 % ee) C−F bond-forming reaction, the fluorination of β-ketoesters with the N-fluorotriethylenediammonium salt F-TEDA [Eq. (1)]. TADDOL=2,2-dimethyl-α,α,α′,α′-tetraaryl-1,3-dioxolan-4,5-dimethanol.