Advanced Synthesis & Catalysis · 2017 · 31 citations · 45 references
PharmacyBiochemistryBiocatalysisBioorganic ChemistryDrug DiscoveryBioactive Natural ProductsOrganic AcidsAntioxidant PropertiesBiocatalytic CarboxylationPhenolic SubstratesPlant PhenolicsRegioselective BiocatalysisRegioselective CatalysisRegioselectivitySubstrate Scope
Abstract In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o ‐benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o ‐Hydroxycarboxylic acid products were obtained with perfect regioselectivity, in moderate to excellent yields. The applicability of this method was proven by the regioselective bio‐carboxylation of resveratrol on a preparative scale with 95% yield. magnified image
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