Concepedia

Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization

Wenzhang Wang, Hiroyuki Arakawa, Luwen Wang, Ogoegbunam Okolo, Sandra L. Siedlak, Yinfei Jiang, Ju Gao, Fei Xie, Robert B. Petersen, Xinglong Wang

Molecular Therapy · 2017 · 93 citations · 31 references

DOIFull text

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Concepts

Abstract

mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

References

31

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Jemeen Sreedharan, Ian P. Blair, Vineeta B. Tripathi et al. · Science · 2008 · 2.6K citations · Full text

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

Edor Kabashi, Paul N. Valdmanis, Patrick A. Dion et al. · Nature Genetics · 2008 · 1.5K citations

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TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

Catalina Amador, Wen‐Lang Lin, Zeshan Ahmed et al. · Annals of Neurology · 2007 · 919 citations · Full text

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Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs

S.-H.I. Ou, F Wu, David Harrich et al. · Journal of Virology · 1995 · 760 citations · Full text

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

Iga Wegorzewska, Shaughn Bell, Nigel J. Cairns et al. · Proceedings of the National Academy of Sciences · 2009 · 707 citations · Full text

, , +17