Concepedia

Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13

Rushikesh Sheth, Iros Barozzi, David Langlais, Marco Osterwalder, Stephen Nemec, Hanqian L. Carlson, H. Scott Stadler, Axel Visel, Jacques Drouin, Marie Kmita

Cell Reports · 2016 · 89 citations · 50 references

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Concepts

Abstract

limbs. Our results show that proper termination of the early limb transcriptional program and activation of the late-distal limb program are coordinated by the dual action of HOX13 on cis-regulatory modules.

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