Journal of Veterinary Medical Science · 2016 · 14 citations · 14 references
Veterinary MedicineImmunologyPathobiologyImmunopathologyInflammationMucosal ImmunologyCytokine BiologyGastrointestinal ImmunologyGastrointestinal InflammationInflammatory Bowel DiseaseMucosal ImmunityMucosal InflammationColonic InflammationEpithelial-derived CytokinesGut-associated ImmunityInflammatory Bowel Disease ImmunopathogenesisInflammatory Bowel Disease PathogenesisInflammatory Bowel Disease PathophysiologyReal-time Polymerase Chain Reaction (Pcr)Th2 Immune Response
It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25, il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs. The results suggest that epithelial cell-derived cytokines may not be an inducer of Th2-type immunity in the gut of dogs with CE, and decreased expression of IL-33 may be involved in induction of FRE. Further studies are required to clarify roles of epithelial cell-derived cytokines, especially IL-33, in the pathogenesis of canine CE.
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The alarmin IL-33 promotes regulatory T-cell function in the intestine
Chris Schiering, Thomas Krausgruber, Agnieszka Chomka et al. · Nature · 2014 · 1K citations