Concepedia

BRAF -mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib

Ikuko Nagasawa, Kazuhiro Kunimasa, Satomi Tsukahara, Akihiro Tomida

Biochemical and Biophysical Research Communications · 2016 · 29 citations · 24 references

DOI

Concepts

References

24

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

Keith T. Flaherty, Igor Puzanov, Kevin B. Kim et al. · New England Journal of Medicine · 2010 · 3.5K citations

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An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

Heather P. Harding, Yuhong Zhang, Huiquing Zeng et al. · Molecular Cell · 2003 · 3.3K citations · Full text

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Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

Heather P. Harding, Yuhong Zhang, Anne Bertolotti et al. · Molecular Cell · 2000 · 2K citations · Full text

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Reinitiation involving upstream ORFs regulates <i>ATF4</i> mRNA translation in mammalian cells

Krishna M. Vattem, Ronald C. Wek · Proceedings of the National Academy of Sciences · 2004 · 1.7K citations · Full text

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