Concepedia

Development of a facile antibody–drug conjugate platform for increased stability and homogeneity

Nimish Gupta, Johny Kancharla, Shelly Kaushik, Aasif Ansari, Samad Hossain, Ravinder Goyal, Manoj Kumar Pandey, Jwala Priyadarsini Sivaccumar, Sazid Hussain, Arindam Sarkar,

Chemical Science · 2016 · 39 citations · 30 references

DOIFull text

Open access

Concepts

Abstract

Pt(<sc>ii</sc>)-based linkers re-bridge the antibody chains<italic>via</italic>strong Pt–S interaction thereby imparting homogeneity, site-specificity and stability to the antibody–drug conjugate.

References

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The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

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