Journal of the American Chemical Society · 2016 · 108 citations · 27 references
Life SciencesBiochemistryMicrobiologyEnzyme MechanismEnzymologyNatural Product BiosynthesisCatalytic MechanismsEnzyme DiscoveryEnzyme KineticsEnzyme-substrate RecognitionFungal BiochemistryFungal Natural Product BiosynthesisBiochemical CharacterizationBiosynthetic Enzyme CharacterizationBiosynthetic Pathway AnalysisBiosynthetic Pathway ElucidationBiosynthetic Pathway EnzymologyEnzyme BiosynthesisFungal Natural Product Pathway ElucidationReaction Mechanism Elucidation
The trans-decalin structure formed by intramolecular Diels-Alder cycloaddition is widely present among bioactive natural products isolated from fungi. We elucidated the concise three-enzyme biosynthetic pathway of the cytotoxic myceliothermophin and biochemically characterized the Diels-Alderase that catalyzes the formation of trans-decalin from an acyclic substrate. Computational studies of the reaction mechanism rationalize both the substrate and stereoselectivity of the enzyme.
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Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A
Hak Joong Kim, Mark W. Ruszczycky, Sei-hyun Choi et al. · Nature · 2011 · 317 citations