Improved and expanded one-pot, two-component Boulton-Katritzky syntheses of N–N bond containing bicyclic heterocycles

Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

N.K. Terrett, Andrew Bell, David Brown et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 606 citations

Medicine, Pharmacology, Pharmacotherapy +12

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2<i>H</i>-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

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Medicine, Oncology, Pharmacology +16

Discovery of 3-[2-(Imidazo[1,2-<i>b</i>]pyridazin-3-yl)ethynyl]-4-methyl-<i>N</i>-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant

Wei‐Sheng Huang, Chester A. Metcalf, Raji Sundaramoorthi et al. · Journal of Medicinal Chemistry · 2010 · 362 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Novel Alternative for the N<i>−</i>N Bond Formation through a PIFA-Mediated Oxidative Cyclization and Its Application to the Synthesis of Indazol-3-ones

Arkaitz Correa, Imanol Tellitu, Esther Domı́nguez et al. · The Journal of Organic Chemistry · 2006 · 105 citations

Natural Sciences, Chemistry, Medicinal Chemistry +11

Acylbenzotriazoles as Advantageous N-, C-, S-, and O-Acylating Agents

Alan R. Katritzky, Kazuyuki Suzuki, Zuoquan Wang · Synlett · 2005 · 99 citations

Natural Sciences, Chemistry, Organic Chemistry +5