Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice

Morris water maze: procedures for assessing spatial and related forms of learning and memory

Charles V. Vorhees, Michael T. Williams · Nature Protocols · 2006 · 4.6K citations · Full text

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Purification and cloning of amyloid precursor protein β-secretase from human brain

Sukanto Sinha, John P. Anderson, Robin Barbour et al. · Nature · 1999 · 1.6K citations

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Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

Patricia Spilman, Natalia Podlutskaya, Matthew J. Hart et al. · PLoS ONE · 2010 · 1K citations · Full text

Life Sciences, Neuroscience, Pharmacology +17