Extended exome sequencing identifies <i>BACH2</i> as a novel major risk locus for Addison's disease

Abstract

Whilst BACH2 has been previously reported to associate with organ-specific autoimmune diseases co-inherited with Addison's disease, we have identified BACH2 as a major risk locus in Addison's disease, independent of concomitant autoimmune diseases. Our results may enable future research towards preventive disease treatment.