Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo

Infection with <i>Trichomonas vaginalis</i> Increases the Risk of HIV‐1 Acquisition

R. Scott McClelland, Laura Sangaré, Wisal Hassan et al. · The Journal of Infectious Diseases · 2007 · 475 citations · Full text

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

Anjan Debnath, Derek Parsonage, Rosa M. Andrade et al. · Nature Medicine · 2012 · 303 citations · Full text

Drug Target, Hit Identification, Health Sciences +11

Inhibition of Schistosoma mansoni Thioredoxin-glutathione Reductase by Auranofin

Francesco Angelucci, Ahmed A. Sayed, David L. Williams et al. · Journal of Biological Chemistry · 2009 · 206 citations · Full text

Prospective Study of Trichomonas vaginalis Infection and Prostate Cancer Incidence and Mortality: Physicians' Health Study

Jennifer R. Rider, Gregory Judson, J F Alderete et al. · JNCI Journal of the National Cancer Institute · 2009 · 187 citations · Full text

<i>Trichomonas vaginalis</i>: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance

David Leitsch, Daniel Kolarich, Marina Binder et al. · Molecular Microbiology · 2009 · 167 citations · Full text

Antiparasitic Agent, Redox Biology, Thioredoxin Peroxidase +18