David Leitsch

<i>Trichomonas vaginalis</i>: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance

David Leitsch, Daniel Kolarich, Marina Binder et al. · Molecular Microbiology · 2009 · 170 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +13

RNA chaperone activity of the Sm‐like Hfq protein

Isabella Moll, David Leitsch, Tanja Steinhauser et al. · EMBO Reports · 2003 · 155 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Nitroimidazole Action in Entamoeba histolytica: A Central Role for Thioredoxin Reductase

David Leitsch, Daniel Kolarich, Iain B. H. Wilson et al. · PLoS Biology · 2007 · 148 citations · Full text

Life Sciences, Biochemistry, Microbiology +16

A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia

Noa Tejman-Yarden, Yukiko Miyamoto, David Leitsch et al. · Antimicrobial Agents and Chemotherapy · 2013 · 143 citations · Full text

Pharmacy, Infectious Diseases, Pharmacology +9

Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia

David Leitsch, Anita G. Burgess, Linda A. Dunn et al. · Journal of Antimicrobial Chemotherapy · 2011 · 131 citations · Full text

Life Sciences, Biochemistry, Microbiology +15